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Guaifenesin/hydrocodone (By mouth)

Guaifenesin (gwye-FEN-e-sin), Hydrocodone (hye-droe-KOE-done)

Treats cough. This medicine contains a narcotic cough medicine.

Brand Name(s):

Vi-Q-Tuss, Atuss HX, Pneumotussin 2.5, EndaCof XP, Vicoclear, Kwelcof, Tusso-DF, Vitussin Expectorant, Hycotuss Expectorant, A-Cof DH, Monte-G HC, Phanatuss-HC Diabetic Choice, FluTuss XP, Canges-XP, Narcof

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to guaifenesin, hydrocodone, or a narcotic. You should not use this medicine if you have a brain tumor, head injury, seizure disorder, or breathing disorder.

How to Use This Medicine:

Liquid, Capsule, Long Acting Tablet

  • Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.
  • Drink plenty of fluids to help avoid constipation.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using pain or arthritis medicine such as diclofenac, etodolac, indomethacin, Daypro®, Dolobid®, Feldene®, Indocin®, Relafen®, Voltaren®.
  • Make sure your doctor knows if you are using a phenothiazine medicine such as Compazine®, Phenergan®, Serentil®, or Thorazine®.
  • Tell your doctor if you are using any medicines that make you sleepy. These include sleeping pills, cold and allergy medicine, narcotic pain relievers, and sedatives.
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breast feeding.
  • Make sure your doctor knows if you have recently had any head injury or stomach problems.
  • Make sure your doctor knows if you have a history of mental illness, alcoholism, or drug addiction problem.
  • This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.
  • This medicine may cause constipation. This is more common if you use it for a long time. Ask your doctor if you should also use a laxative to prevent and treat constipation.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Blurred vision.
  • Change in how much or how often you urinate.
  • Light-headedness or fainting.
  • Pain while passing urine.
  • Pounding heartbeat.
  • Severe headache.
  • Trouble breathing.

If you notice these less serious side effects, talk with your doctor:

  • Anxiety or mood changes.
  • Confusion or fear.
  • Mild nausea or vomiting.
  • Weakness.

Last Updated: 4/4/2008

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