Collagenase (koe-LAJ-en-ase)

Used to clean skin ulcers and severe burns.

Brand Name(s):

Santyl

When This Medicine Should Not Be Used:

How to Use This Medicine:

Ointment

• Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
• This medicine is for use on the skin only. Do not get it in your eyes, nose, or mouth. Do not use it on skin areas that have cuts or scrapes. If it does get on these areas, rinse it off right away.
• Wash your hands with soap and water before and after using this medicine.
• This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

How to Store and Dispose of This Medicine:

• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
• Ask your pharmacist, doctor, or health caregiver about the best way to dispose of the used medicine container and any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
• Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Do not use cosmetics or other skin care products on the treated skin areas.
• Make sure your doctor knows if you are using soaps, antiseptic creams, or solutions.

Warnings While Using This Medicine:

• Do not use this medicine for a skin problem that has not been checked by your doctor.
• Make sure your doctor knows if you have any infections, or if you develop any infections while using this medicine.
• Make sure your doctor knows if you have other medical problems.
• If your symptoms do not improve or if they get worse, call your doctor.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.

If you notice these less serious side effects, talk with your doctor:

• Redness or rash around the wound area.