Pronunciation:

roe (D) im-MYOON GLOB-yoo-lin

Brand Names:

• BayRho-D
• HyperRHO S/D
• MicRhogam Ultra-Filtered
• Rhogam
• RhoGAM Ultra-Filtered Plus
• Rhophylac
• WinRho SDF
• Winrho SDF

Dosage Forms:

• Solution
• Injectable
• Powder for Solution

Classifications:

Therapeutic—

Immune Serum

Uses of This Medicine:

Rh o(D) immune globulin is used to prevent your body from interacting with any of your baby's blood that may get into your blood system while you are pregnant or during the delivery of your baby. If your blood type is Rh o(D) negative and your baby's blood type is Rh o(D) positive, your body may produce a defense (antibodies) against Rh o(D) positive blood. These antibodies usually will not cause a problem if this is your first pregnancy, unless you have had a blood transfusion in the past and have already developed these antibodies. However, if you have other Rh o(D) positive babies in the future, these antibodies may try to destroy the blood of the future babies. If this occurs, it is a very serious condition. Babies born with this condition may need to have their blood replaced.

Rh o(D) immune globulin can be used to treat immune thrombocytopenic purpura, a type of blood disorder. This medicine may be helpful to prevent excessive bleeding.

Rh o(D) immune globulin may also be used if you have recently received a transfusion that contained Rh o(D) positive blood and your blood type is Rh o(D) negative.

Rh o(D) immune globulin is to be administered only by or under the supervision of your doctor or other health care professional.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Studies on this medicine have been done only in adult patients and there is no specific information comparing use of Rh o(D) immune globulin in children with use in other age groups.

Pregnancy—

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast-feeding—

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Immunoglobulin A (IgA) deficiencies—Rh o(D) immune globulin may cause an allergic reaction to occur
• Rh o(D) positive patients with immune thrombocytopenic purpura, ITP (a type of blood disorder)—Should be monitored for anemia and kidney problems

Proper Use of This Medicine:

Dosing—

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For injection dosage form:
  • To prevent your body from producing antibodies against Rh o(D) positive blood:
    • Adults and children—One or more injections, depending on how much Rh o(D) positive blood has gotten into your blood system. The medicine may be used during your pregnancy, within 72 hours after your baby is born, at the end of an incomplete pregnancy (abortion, miscarriage), or after a transfusion. The medicine is usually injected into a muscle, although it may be injected into a vein.
  • To help prevent excessive bleeding in patients with immune thrombocytopenic purpura, ITP (a type of blood disorder):
    • Adults and children—One or more injections, depending on factors in your blood. The medicine is injected into a vein.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Rare

Bloody urine

decreased frequency of urination or amount of urine

increased blood pressure

increased thirst

loss of appetite

lower back pain

nausea or vomiting

pale skin

swelling of face, fingers, or lower legs

troubled breathing

unusual bleeding or bruising

unusual tiredness or weakness

weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Fever

soreness at the place of injection

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.